|
KMID : 0363320030240020249
|
|
Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 2 p.249 ~ p.259
|
|
|
The Inhibitory Effects of SoCheongRyongTang(SCRT) on Cytokine Production and Secretion of IgE in Highly Purified Mouse B cells
|
|
Bae Han-Ho
Lee Joung-Eun
Han Young-Ju
Park Yang-Chun
|
|
|
Abstract
|
|
|
Objective : We aimed to identify the inhibitory effects of SocheongRyoungTang on Cytokine Production and Secretion of IgE in Highly Purified Mouse B cells. This experiment was designed to investigate the effect of SoCheongRyongTang(SCRT) on Antiallergy.
Materials and Methods : We measured the cytotoxic activity for cytokines transcript expression, production of IL-1{beta},;IL-4,;IL-6,;IL-10,;IFN-{gamma},;TNF-{alpha},;TGF-{beta} proliferation of B cell in anti-CD40mAb plus rIL-4 plus HRF stimulated murine splenic B cells and histamine in anti-CD40mAb plus rIL-4 plus HRF stimulated mast cells.
Results : 1. SCRT increased the gene synthesis of IFN-{gamma}(m-RNA), the appearance of IL-10, IFN-{gamma}. 2. SCRT decreased the gene synthesis of IL-l{beta},;IL-4,;TGF-{beta}(m-RNA) and the appearance of IL-l{beta},;IL-4,;TGF-{beta},;IgE significantly.
Conclusion : SCRT decreased the proliferation of B cell significantly. According to the above results, it is suggested that SCRT extract might be usefully applied for prevention and treatment of Allergic disease.
|
|
|
KEYWORD
|
|
|
SoCheongRyongTang, Cytokine, IgE, Antiallergy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|